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NC Diva,   Thanks for your question.  High blood pressure alone will not cause fluid retention in the hands.  If a person has congestive heart failure, this can cause fluid to build up in the feet, legs, lungs, and sometimes the hands.    If one of your medications contains a strong diuretic, many patients observe fluid retention if they miss a couple of doses.  But this is usually mild.  Not taking your meds may result in your pressure rising, but again, it is doubtful that this is the cause of the swelling.   Because there are some unusual conditions that can cause hand swelling, I suggest you see your physician for his evaluation and opinion.       I hope this has been helpful.  Be sure to review our website for more information about high blood pressure, medications used to treat it, as well as tips on lifestyle and diet that will help keep things under control.   Martin Cane, M.D.