• John John
    October 26, 2008
    Weaning off clonidine?
    John John
    October 26, 2008

    Every time I try to get off clonidine but when I stop taking it, my heart rate and blood pressure go way up.  I also experience anxiety when trying to taper off the med.  What do I do? Is it really possible to get off clonidine completely and my body return to normal?



  • Martin Cane, M.D.
    Health Pro
    October 27, 2008
    Martin Cane, M.D.
    Health Pro
    October 27, 2008

    Clonidine is a powerful blood pressure medication that requires monitoring and regulation by your doctor.  This medication can cause a dangerously high blood pressure in some people when the medication is discontinued, which is known as rebound.  For this reason, your doctor should be the person who is lowering your medication and monitoring your pressure during this process.  Other medication might be necessary to keep your blood pressure controlled.


    To answer one of your questions: No, you cannot do this alone.  You need your doctor's help and guidance. 


    Here are some articles you might find helpful as you're going through this:


    7 Lifestyle Strategies to Decrease Your Risk of a Blood Clot


    Not Overweight, But Still At Risk for Heart Disease


    How to Find the Best Blood Pressure Monitor  


    • John
      January 11, 2010
      January 11, 2010

      Other than being under a doctor's supervision and the use of other medication for bp control, what is the formula (e.g., half the dose every few days or week, or reduce by .05 every few days or week)?  I am taking .1 x 3.  Surely, there has to be formula for weaning off this drug.  Thanks........

    • Darlene Knight
      November 20, 2014
      Darlene Knight
      November 20, 2014
      All call it the Devil because every since I've been on it, it's been controlling my life been on it for 8 years now and I want off of it so bad so I decided to go to ask.com and typed in how to wean off of it to get on the site and see so many people wanting to knw the same thing makes me even more scared 1 time I stop taking it just to see if it will affect me and I ended up in the hospital with a racing heart high blood pressure and mind gone doctors tried to wean me off several of times never succeeded because every time I try my heart rate goes up and then I'm having racing thoughts confused can't find things tht are right their irritable depressed and etc and I want my life back I have 2 kids and it's effecting my ineracting with them and I'm tired can anybody help or give advice? READ MORE


  • Upset Doctor May 19, 2013
    Upset Doctor
    May 19, 2013



    To the suffering guys on Clo:


    Clonidine is one very addictive medication that my colleagues should stop prescribing so easily!! I see a few mistakes were made. They did not lower dose gradually by 25% off every few days. And starting bystolic immediately after actually interacts with Clonidine, beta blockers make Clonidine rebound worse. In the leaflet of Clonidine, it says there should be a week between discontinuing beta blockers and dicontinuing Clonidine. Also: bystolic is an equally addictive drug that takes about 1 month to work. Shoudl NEVER start w 10 mg, but with 5 mg and gradually increase. NEVER ABRUPLY START OR DISCONTINUE, unless you want to visit an ER every week with even worse effects on pocket and health.


    PS. Do not let idiots post dirty words on this website. They have no business here, they should be banned.

    • mcs2014
      April 08, 2014
      April 08, 2014
      Other than moderate hypertension the last few years, I am an otherwise healthy and fitness-minded athletic male of 54. I had been treating my HTN naturally until this year when I decided to try some pharmaceutical intervention. I apologize for being long-winded, but I have a lot to go over and your comments prompted me to post, hoping you (and others) could provide any assistance in successfully getting off Clonidine, as I’ve am having lots of trial and error and my nerves can take anymore. Wish my doc had never started me on the 0.2mg Clonidine transdermal patch back in mid-Feb., as I originally suggested we try an ACEI; he thought the transdermal would be a better alternative to the oral Clondine. Despite it lowering BP, I didn't like the continuing side effects (dry mouth, lethargy, orthostatic hypotension).I was aware of Clonidine rebound, having used the tablets in small doses but only for 1-3 days at a time and never experienced any significant or noticeable rebound. I therefore thought the patch was less likely to cause it, so I removed it after only NINE DAYS of being on it, also assuming I hadn't been on it long enough to cause any rebound. I was dead wrong. Within 36 hrs, I experienced my first rebound (BP 180/100 + the typical hyperadrenergic symptoms of tremor, anxiety, tachycardia). Since then, I have experienced five additional rebounds and have been struggling to taper off, moving from the 0.2mg to a 0.1mg patch and then off the patch completely. In each case of dropping the dose, the rebound occurred; obviously too much of a decrease, despite trying Verapamil (80mg TID) and finally adding Lisinopril (10mg qd). I had been on the patch system for only 48 days and now after my most recent rebound yesterday, am on oral Clonidine.  I finally was able to have a compounding pharmacy make me up some 0.025mg capsules to help taper down from my last “addiction” set point of the 0.1mg patch. These ¼ dose caps were my idea, so I don’t know if it’ll work, but the docs agreed with me to move forward.A pharmacist suggested perhaps to double the dose of Lisinopril, but after doing much research, successful pre-treatment management of Clonidine withdrawal and rebound always involved using a beta-blocker concomittantly, so I explained to my doc we need a catecholamine depletor to accomplish this. He prescribed Bystolic. But when I further researched this drug in combination with Clonidine and that it may worsen the rebound + reading your posted comments above, I freaked out. I showed my notes to both docs, the ER doc, and a pharmacist and all said that these effects are highly unlikely and only occur in rare cases. Yet I’m still not 100% confident. I certainly don’t want another monkey on my back to fight off rebound!This is an older study in which the subjects were on long-term therapy, at higher doses, and stopped cold turkey (not something I would ever do again): http://deepblue.lib.umich.edu/bitstream/handle/2027.42/33890/0000155.pdf?sequence=1The question is: a) do I really need a catecholamine depletor like Bystolic (that can also help reduce the non-blood pressure symptoms) during my weaning off protocol, or b) should I just try using the 0.025mg caps without any other meds, and taper of 1 cap every 4-5 days as you suggested? What if I rebound AGAIN?Or maybe use a benzo to manage the anxiety?I am praying that I will have an easier time weaning off the tabs as opposed to the patch. I truly hate to be on any meds, but in this case, I feel I must fight fire with fire.I can only imagine how acute the rebound effects are for those poor folks trying to stop from long-term therapy! I therefore think that the patch system is more “addicting” than the tablets because of the continuous release of active medication being released into the bloodstream 24/7, hence my rebound symptoms. Do you agree?Thanks for your assistance! READ MORE
    • Lee James
      May 13, 2014
      Lee James
      May 13, 2014
      I have been on Clonidine .1 mg 4x day for 2 years to control paroxysmal hypertension. I have cardiovascular disease, with 2 stents in my heart and have had an endarterectomy for carotid stenosis. Of course, this was an incredibly stupid treatment plan for a patient with cardiovascular disease. It has resulted in my being basically bedridden for two years—the worst possible result. In addition, Clonidine, nor any other drug, does not prevent paroxysmal hypertension. The only thing that can prevent it is surgery if it is due to pheochromocytoma. Unfortunately, mine is not due to a pheo, so no quick fix for me. Paroxysmal hypertension can NOT be prevented. It can only be treated when it occurs. A study of 14 hospitalized and stabilized patients showed that after 60 hours of being off Clonidine there was no more spike risk. It's getting from 0 to 60 that is the problem. I finally had to do it myself, after screwing around with idiot cardiologists while trying to get off it for almost a year. I did it by reducing each dose 50% until my body completely adjusted and I was experiencing the same side effects I had been experiencing at full dose. That is, extreme lethargy, very low blood pressure, and very low pulse rate. Then I stopped one dose completely—the dose that seemed the least necessary. For me, it was the dose I took at noon, but it might be different for other people. My BP spikes when I first wake up, as does everyone's, but my most dangerous time is evening to night. I stopped those half-doses one at a time, each time waiting for my body to adjust. In my case, it took about a week after stopping each dose before I was convinced there was no further risk and I could stop another dose. Go very slowly. If your BP spikes, go to the ER and tell them what you're doing and ask them to treat your spike with something other than Clonidine. You need to know that one of the side-effects of Clonidine is anxiety. You may be more anxious after using it than you were before you started it, and not aware of this because it makes you so lethargic. When you start coming off it, anxiety may be part of the challenge. Short-term low-dose Xanax works well—just be careful to not trade one monkey for another. Clonidine is a wonder drug for treating paroxysmal hypertension so long as it is used ONLY paroxysmally. Unfortunately, it has been my experience that non-pheo paroxysmal hypertension is not well understood and that cardiologists are among the most myopic and least rational people on earth. Dangerous, dangerous folk. If they don't understand your disease, they'll just treat you for a disease you don't have and destroy both your health and life. More money for them—at least until they kill you. READ MORE
  • BOb the builder July 22, 2012
    BOb the builder
    July 22, 2012

    FUCk you

  • Hermit June 25, 2011
    June 25, 2011

    Worse damn HPB medicine ever!!!  Was taking 0.2 three times a day for over three years. Withrew over period of eight days.  Been completely off it for past 12 days and feel terrible.  Blood pressure is running 190's over 110's.  Was started on bycolic 10 mg once a day (beta blocker)and teckturna 150mg (renin inhibitor) once a day but hasn't lowered my blood pressure.  Wish my doctor had never started me on this horrible drug.

  • Debbie June 13, 2014
    June 13, 2014

    Hey I hope this will help, I have been on Clonidne for 2 years for high blood pressure and not being able to sleep, i recently got severe withdrawal symptoms one day by taking the pill at the wrong time of the day.( vomiting, violent uncontrolable shakes, dizzyness, dry mouth, increased heartrate} I recently asked my doctor to lower my dosage so I can get this mess out of my system, so she dopped it from 0.2 to 0.1 for 14 days and 1/2 after seven days. I am only one day two taking 0.1 and i have had no sypmtoms for the first night of taking a lower dosage. I would advise you to speak with your doctor before you do anything on you own because it all depends on how much you were prescribed and how often you take it. This drug is extremely dangerous by stopping cold turkey so its better to taper off,( the day I took it at the wrong time the night I skipped was so horrible I went to the er where they gave me Zofran for nausea and vomitting) I was considering purchasing over the counter sleep aids once i completely lower my dose.  They do not want to legalize marijauna but are prescribing precription drugs that are like meth once you stop. I am exercising daily to help with my pressure.  If i would have known the effects of this drug when I was prescribed I would have never started it. 

  • Ms.Monroe August 25, 2011
    August 25, 2011

    Wow!I'm relieved to see other people having the exact same problem with Clonidine. I was put on .2mg 3x a day after being diagnosed with Post traumatic stress disorder after almost dying after being hit by a drunk driver(on a Sunday morning!).Anyway,Clonidine is one of the biggest nightmares I have ever encountered. If I don't take a full dose every few hours I literally start going into an almost immidiate withdrawl that has landed me in the ER 3 times because of the rebound Hyper tension.I also have gained 30 pounds because I'm so lethargic,I can't even begin to think about jogging around the block.I am also on 2 other blood pressure medications,and found this forum out of desperation to wean myself off of Clonidine and still be a functioning person.Has anyone else been successful with doing so and if so,how did you take down your dosage? At my last Doctors appointment I pleaded with my doctor to take me off of Clonidine and  was immidiatly shut down with a "This is the best Medication for PTSD,no."Nice.I would love to hear back from anyone with advice regarding this topic. Now I'm off to take my Clonidine for the morning since I'm startng to shake-yay!Yell

  • regulator August 20, 2012
    August 20, 2012

    i wish doctors would tell people of such conditions before prescibing such medications..there should be something done about this..ny doctor put me on this medication also, its been a nightmare, constipation and muscle aches, this nedication should be banned






  • bonehead7020 October 02, 2015
    October 02, 2015
    Doctors are supposed to wean you off clonidine....I have been on clonidine for years and can't seem to get off of it.....any suggestions?? READ MORE
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