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Hi James, I understand your concern about the safety of Diovan. Actually, Diovan has some kidney protective effects, and can actually help kidney function in patients. I would recommend that you take the medication if your doctor has prescribed it for you; he should be aware of your medical conditions and shouldn't prescribe you something if there is the possibilty that it could do more harm then good. I would also recommend that you start an exercise regimen and maintain a healthy diet (if you don't do this already) which can also help to lower your cholesterol. Thanks for your question! Jill