Is there any drug reaction with Crestor and Melotonin

Socialr,

Thanks for your question. 

Crestor is a statin class of cholesterol lowering medication.  Melatonin is a natural substance produced by the brain that is important for inducing and maintaining sleep, and plays an important part in the circadian rhythm, or sleep/awake cycles of the brain.  It is available as a supplement without a prescription. 

There is no documented contraindication to using both at the same time.  However, some preliminary research has demonstrated that melatonin can raise cholesterol levels and therefore some manufacturers are suggesting caution in patients with high cholesterol and vascular disease.  I was unable to find any data that indicated how much the cholesterol was affected by the melatonin.  Though safe to take together, I would ask your doctor about the cholesterol aspect of the melatonin, and how much this may have contributed to your cholesterol levels. 

I hope this has been helpful.

Martin Cane, M.D.