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Wednesday, November 11, 2009
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BiDil Oral

Precautions and Side Effects


Generic Name: ISOSORBIDE DINITRATE/HYDRALAZINE - ORAL
Pronounced: (EYE-soe-SOR-bide dye-NYE-trate/hye-DRAL-a-zeen)

BiDil Oral Side Effects

Table of Contents

Headache, dizziness, lightheadedness, nausea, and flushing may occur as your body adjusts to the medication. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Headache is often a sign that this medication is working. Your doctor may recommend treating headaches with an over-the-counter pain reliever (such as acetaminophen). If the headaches continue or become severe, tell your doctor promptly.

To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

This medication may infrequently cause nerve problems. Tell your doctor promptly if you experience numbness or tingling. Your doctor may recommend a vitamin B6 supplement (pyridoxine).

Tell your doctor immediately if any of these unlikely but serious side effects occur:

  • severe tiredness
  • aching/swollen joints
  • rash on nose and cheeks
  • swollen glands
  • change in the amount of urine
  • bloody/pink urine
  • signs of infection (such as fever, chills, persistent sore throat)
  • easy bruising/bleeding
  • fainting
  • fast/irregular/pounding heartbeat


Seek immediate medical attention if this rare but serious side effect occurs:

  • chest/jaw/left arm pain


A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction:

  • rash
  • itching/swelling (especially of the face/tongue/throat)
  • severe dizziness
  • trouble breathing


This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. In the US, you may report side effects to the Food and Drug Administration (FDA) at 1-800-FDA-1088.

In Canada, you may report side effects to Health Canada at 1-866-234-2345.

BiDil Oral Medical Alert

Your condition can cause complications in a medical emergency. For information about enrolling in MedicAlert, call 1-800-854-1166 (USA) or 1-800-668-1507 (Canada).

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