The results of a recent study published in this month's edition of Genes and Immunity suggest new links to Crohn's disease and evidence of increased risk for IBD among people of Jewish descent.
The study is believed to be the largest of its kind to date and included information from 993 families with inflammatory bowel disease, of which 244 were of Ashkenazi Jewish descent. Results came after analyzing single nucleotide polymorphisms (SNPs), common DNA variants. The study found that up to 30% of people diagnosed with IBD in the U.S. have a family history of the disease. In addition, Ashkenazi Jews were twice as likely to develop IBD and more likely to have a family history of the disease.
The senior author of the study, Johns Hopkins gastroenterologist and genetic investigator Steven R. Brant, M.D. said, "What makes these results especially significant is not only the large sample size but also the method we used for screening, namely the use of a high-density, single-nucleotide polymorphism genome-wide linkage process."
Published On: March 31, 2008