At what point does having your colon removed become an option? I have UC, was diagnosed almost 4 years ago, and haven't quite been able to get a flare under control for the past year. I was switched from Sulfasalazine to Asacol last summer when I initially flared, but then I slipped back into a terrible flare at the beginning of this year (which I think was partly caused by a switch to Lialda - I don't think my body was taking to the time-released doses). I started 6-MP more than 6 months ago, and was on Prednisone until a couple weeks ago (still on Asacol - 12 pills per day). I was being tapered off the Pred, and I was doing okay, but after being completely off Pred for only 2 weeks, I was already starting to see bad signs in my bowel movements... and then last night I was very sick. My doctor thinks it was something I ate and just wants to watch me for the next week or so. But I'm sick of this! If it turns out to be a flare again/still, I don't know if I want to try a higher dose of 6-MP or switch to Remicade! And I'm also worried that I'm a high risk for colon cancer in the future. Would it just be better to have my colon removed?