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Hi Alaura,   I'm sorry your situation is so frustrating. This is actually a web site for people who have IBD - Inflammatory Bowel Disease, not IBS. You can read my most recent Sharepost about the difference between IBD and IBS.   From what you have written here is sounds like you've had a colonoscopy which would tell you if you have IBD - Ulcerative Colitis or Crohn's Disease - and the doctors have said, "No."   NSAIDS, especially prolonged or long-term use of them can mess with you gut quite badly. If I were you I would stop taking them and for pain relief take only Tylenol for at least a few months and see what happens. Also, if you aren't satisfied with your diagnosis then you are going to have to seek out another doctor, take him or her all of your test results and medical records, and get their opinion.   IBS is a diagnosis of exclusion, and once all other medical diagnoses have been ruled out for your symptoms, then the IBS diagnosis is given. Have you talked to your OB/GYN about things like Endometriosis? Fibroids? etc. Abdominal cramps and pain can be caused by more than gut issues.   Sorry I don't have an answer for you. You could try the IBS web site www.ibsgroup.org and see if anyone there has some thoughts for you.   Good luck, Elizabeth