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For me personally, the Flora-Q probiotic formula has been very beneficial.  It is the brand recommended by my gastroenterologist.  When you first begin taking them, you may feel a little more gassy and bloated than usual but this typically resolves in a couple of days.  After that, you may not notice a significant difference in how you feel until you miss a couple or stop taking the capsules.  Again, from my experience, that's when the really bad bloating and discomfort set in.  Getting right back on them resolves that issue.    I think they are great.  I've never felt more "balanced" since I've started using these probiotics.   BTW, the Flora-Q formula does not need to be kept refrigerated provided it is kept at 77 degrees Fahrenheit or less.