Cipro XR Oral

Cipro XR Oral Interactions

See also the How to Use section.

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.

This drug should not be used with the following medications because very serious interactions may occur:

• strontium
• tizanidine
• certain drugs that affect the heart rhythm (antiarrhythmics that may cause QT prolongation such as amiodarone, dofetilide, quinidine, procainamide, sotalol)

If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting ciprofloxacin.

Other drugs besides ciprofloxacin and those listed above that may affect the heart rhythm (QT prolongation in the EKG) include certain macrolide antibiotics (e.g., erythromycin, clarithromycin), and certain antipsychotic medications (e.g., pimozide, thioridazine, ziprasidone), among others. QT prolongation can infrequently result in serious (rarely fatal) fast/irregular heartbeat and other symptoms (e.g., severe dizziness, fainting) that require immediate medical treatment. Ask your doctor or pharmacist for more details and for instructions on how you may reduce the risk of this effect.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of:

• live bacterial vaccines (e.g., typhoid, BCG)
• "blood thinners" (e.g., warfarin)
• corticosteroids (e.g., prednisone, hydrocortisone)
• cyclosporine
• drugs removed from your body by certain liver enzymes (such as clozapine, duloxetine, phenytoin, ropinirole, tacrine)
• drugs for diabetes (e.g., glyburide, insulin)
• methotrexate
• nonsteroidal anti-inflammatory drugs (NSAIDs such as ibuprofen, naproxen)
• certain "water pills" (potassium-wasting diuretics such as furosemide, hydrochlorothiazide)
• probenecid
• sevelamer
• theophylline
• urinary alkalinizers (e.g., potassium/sodium citrate)