Cipro XR Oral

Cipro XR Oral Interactions

See also the How to Use section.

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.

This drug should not be used with the following medications because very serious interactions may occur:

• strontium
• tizanidine

If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting ciprofloxacin.

Many drugs besides ciprofloxacin may affect the heart rhythm (QT prolongation), including amiodarone, dofetilide, quinidine, procainamide, sotalol, certain macrolide antibiotics (e.g., erythromycin, clarithromycin), and certain antipsychotic medications (e.g., pimozide, thioridazine, ziprasidone), among others. Therefore, before using ciprofloxacin, report all medications you are currently using to your doctor or pharmacist.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of:

• live bacterial vaccines (e.g., typhoid, BCG)
• "blood thinners" (e.g., warfarin)
• corticosteroids (e.g., prednisone, hydrocortisone)
• cyclosporine
• drugs removed from your body by certain liver enzymes (such as clozapine, duloxetine, phenytoin, ropinirole, tacrine)
• drugs for diabetes (e.g., glyburide, insulin)
• methotrexate
• nonsteroidal anti-inflammatory drugs (NSAIDs such as ibuprofen, naproxen)
• probenecid
• sevelamer
• theophylline
• urinary alkalinizers (e.g., potassium/sodium citrate)

Also report the use of drugs that might increase seizure risk when combined with this medication such as isoniazid (INH), phenothiazines (e.g., chlorpromazine), or tricyclic antidepressants (e.g., amitriptyline), among others. Consult your doctor or pharmacist for details.

Avoid drinking large amounts of beverages containing caffeine (coffee, tea, colas), eating large amounts of chocolate, or taking over-the-counter products that contain caffeine to keep you awake and alert. This drug may increase and/or prolong the effects of caffeine.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.