Crohn's and Biologics--- At What Point Should They Be Used?
For years, the treatment of Crohn's disease has been based on a "step-up" approach in which therapies with the least toxicity are used early, and subsequent therapies are then added due to lack of response or toxicity. Unfortunately, agents with low efficacy such as the aminosalicylates, Asacol and Pentasa, are used for prolonged periods of time while uncontrolled inflammation results in tissue damage. Patients who fail to respond...

