Detrol Oral Interactions

Your healthcare professionals (e.g., doctor or pharmacist) may already be aware of any possible drug interactions and may be monitoring you for it. Do not start, stop or change the dosage of any medicine before checking with them first.

This drug should not be used with the following medication because very serious interactions may occur:

• pramlintide

If you are currently using the medication listed above, tell your doctor or pharmacist before starting tolterodine.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of:

• anticholinergic drugs (e.g., atropine, scopolamine)
• other antispasmodic drugs (e.g., dicyclomine, propantheline)
• certain anti-Parkinson's drugs (e.g., benztropine, trihexyphenidyl)
• belladonna alkaloids
• potassium tablets/capsules
• drugs affecting liver enzymes that remove tolterodine from your body (such as azole antifungals including itraconazole and ketoconazole; macrolide antibiotics including clarithromycin and erythromycin; cimetidine; cyclosporine; rifamycins including rifabutin; St. John's wort; certain anti-seizure medicines including carbamazepine; vinblastine)

Many drugs besides tolterodine may affect the heart rhythm (QT prolongation), including amiodarone, dofetilide, pimozide, procainamide, quinidine, sotalol, macrolide antibiotics (such as erythromycin), among others. Therefore, before using tolterodine, report all medications you are currently using to your doctor or pharmacist.

Tell your doctor or pharmacist if you also take drugs that cause drowsiness such as: certain antihistamines (e.g., diphenhydramine), anti-anxiety drugs (e.g., diazepam), anti-seizure drugs (e.g., phenobarbital), medicine for sleep (e.g., zolpidem), muscle relaxants, narcotic pain relievers (e.g., codeine), psychiatric medicines (e.g., phenothiazines such as chlorpromazine or tricyclics such as amitriptyline), tranquilizers.

Check the labels on all your medicines (e.g., cough-and-cold products) because they may contain drowsiness-causing ingredients. Ask your pharmacist about the safe use of those products.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.