Generic Name: INTERFERON BETA 1A - SUBCUTANEOUS INJECTION
Pronounced: (in-ter-FEER-on bay-tah)

Rebif SubQ Precautions

Before using interferon, tell your doctor or pharmacist if you are allergic to it; or to products containing human albumin; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Some brands of this medication contain albumin made from human blood. Even though the blood is carefully tested, and this medication goes through a special manufacturing process, there is an extremely small chance that you may get infections from the medication (for example viruses such as hepatitis). Consult your doctor or pharmacist for more information.

Before using this medication, tell your doctor or pharmacist your medical history, especially of:

• blood problems (e.g., anemia, low platelets, low white blood cells)
• heart disease (e.g., heart failure, irregular heartbeat)
• liver disease
• mental/mood disorders (e.g., depression, psychosis, suicidal thoughts)
• seizures
• thyroid disease
• history of alcohol dependence

Limit alcoholic beverages while using this medication. Ask your doctor or pharmacist about how to drink alcohol safely while using this drug.

This medication is not recommended for use during pregnancy. It may harm the unborn baby. If you become pregnant or think you may be pregnant, inform your doctor immediately. Consult your doctor for more details.

It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.

Rebif SubQ Side Effects

Pain, redness, or swelling at the injection site may occur. If any of these effects persist or worsen, tell your doctor promptly.

Flu-like symptoms such as headache, nausea, fever, chills, tiredness, and muscle aches/pain may occur, especially when you first start this medication. You can reduce these side effects by injecting this medicine at bedtime and using fever reducers/pain relievers such as acetaminophen or ibuprofen. Consult your doctor or pharmacist for more information.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including:

• mental/mood changes (e.g., depression, rare thoughts of suicide)
• vision changes
• gradual change in weight
• intolerance to cold or heat
• increased urination
• signs of infection (e.g., fever, persistent sore throat, cough)
• easy bruising/bleeding
• fast/irregular heartbeat
• sudden increase in weight
• swelling hands/legs/feet
• severe stomach/abdominal pain
• yellowing eyes/skin
• dark urine

Get medical help right away if any of these rare but very serious side effects occur:

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