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That's a question that can only be answered by trying it, Seakat.  If the prometrium is having a positive action on your sleep and mood (which are 2 of its possible effects), you will notice more sleep disturbance and possibly mood swings.  If you're on estrogen, you most likely will not have return of hot flashes.  If your benefit from Prometrium is primarily the uterine protection, you should notice little to no difference. Wish I could give you a straighter answer...but, as everything in menopause, it's all individual! Best regards, Sandy Greenquist, CNM Menopause Clinician
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