I have not had a period for a year. I was having horrible hot flashes and night sweats and could not sleep. My doctor prescribed 1mg of Estradiol and 100mgs of Prometrium daily. I have been taking it for 3 months. The hot flashes are gone and I am sleeping like a baby. But, I have gained 10 pounds. I have never had problems with weight gain in my life. I exercise regularly and have a pretty good diet. Is it the drugs? And if so, I will probably stop taking them and deal with the hot flashes. How should I go about stopping? I can break the Estadiol in half but not the Prometrium?