FROM OUR EXPERTS
Dr. Ravdin et al published a very impressive article in this week's New England Journal of Medicine on hormone replacement therapy (HRT) use and breast cancer rates.
They showed that the incidence (number of new cases) of breast cancer decreased in women who were 50 years of age or older from 2002 through the end of 2004.
They tie this to the decrease in postmenopausal hormone replacement therapy and note that the decrease was largely in the number of new cases of estrogen receptor positive (ER+) tumors.
The data on hormone replacement therapy and its relation to an increased incidence of breast cancer has been well publicized, although my latest take on the most recent iteration was that use for several years after menopause did not really increase the risk of breast cancer – that the increase was in women who had used hormone replacement therapy for 10 years or longer.
The hormone replacement therapy study is an interesting article and well thought out, and the au...
At the San Antonio Breast Cancer Conference in December 2006 a major presentation linked the drop in new cases (incidence) of breast cancer to the decline in the use of postmenopausal hormone replacement therapy . Many were skeptical that this was a true cause and effect, and some postulated that the decline was not due to a decrease in the number of new cancers, but a decrease in their detection due to fewer women having mammograms . If women were less vigilant and not undergoing mammography than the number of new cases would decline - although probably only for a few years. Fewer mammograms would also mean the cancers would be detected at more advanced stages. A new study adds evidence that the decline is due to a decrease in hormone therapy rather than a decrease in mammography - published in the Journal of the National Cancer Institute. Some of the controversy was raised in a series of letters to the New England Journal of Medicine. They pointed o...
For those with Migraines, the question of whether to use hormone therapies is one we often look at only in terms of the impact it will have on Migraine frequency and severity. There are, however other issues that need to be considered as well. Two new studies show that hormone therapy (HT) for women is linked to brain shrinkage, but not to the small brain lesions that are the first sign of cerebrovascular disease. The studies are published in the January 13, 2009, print issue of Neurology® , the medical journal of the American Academy of Neurology. Earlier studies showed that estrogen with or without added progestin increased the risk for developing dementia and cognitive decline, or difficulty with thinking skills and memory in women age 65 and older. These new studies aimed to look at how the hormones might affect memory and thinking skills. The studies involved participants of the Women’s Health Initiative* hormone therapy clinical trials who also agreed to...
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