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Doing research on menopause and hives and came across your post. I am 50 and have been perimenopusal for about 4 years. Three weeks ago I came down with severe hives. Aren't they indeed miserable? I treated them with OTC antihistamines, as you have done, and they seemed to help after a week or so. But they made me so dizzy and foggy that I stopped using them, and now the hives are back, driving me crazy. Right now I'm relying on an antihistamine cream (Benadryl makes one) that I apply as soon as I feel the roving itching begin. It takes a few minutes, but it seems to tone down the itching and swelling for a time. I intend to keep looking around for an effective treatment, and it is somewhat comforting to know I am not alone. I've been hearing about the role that hormones may play in the suffering of hives for perimenopausal and menopusal women, but thus far nothing definitive. Let me know if you find some miracle solution, and I'll do the same!