Biopsy

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Biopsy

Definition:

A biopsy is the removal of a small piece of tissue for microscopic examination and/or culture, often to help the physician make a diagnosis.

Alternative Names:
Tissue sampling
How the test is performed:

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The method of tissue removal varies among the type of biopsies:

In a needle (percutaneous) biopsy, the tissue sample is simply obtained by use of a syringe. A needle is passed into the tissue to be biopsied, and cells are removed through the needle. Depending on the location of the tissue to be biopsied, needle biopsies are often performed under X-ray (usually CT scan) guidance.
In an open biopsy, an incision is made in the skin, the organ is exposed, and a tissue sample is taken.
Closed biopsy involves a much smaller incision than open biopsy. The small incision is made to allow insertion of a visualization device, which can guide the physician to the appropriate area to take the sample.

If the tissue to be sampled is in the abdomen and cannot be safely accessed with a needle or closed procedure, an open biopsy must be performed in the operating room.

How to prepare for the test:

Check with your physician about stopping medications that can predispose to bleeding, such as aspirin, Coumadin, and nonsteroidal anti-inflammatory medications (NSAIDs). Also mention any herbal preparations you are taking. Never change your medication regimen without first checking with your physician.

How the test will feel:

In a needle biopsy, you will feel a small sharp pinch at the site of the biopsy. In an open or closed biopsy, local or general anesthesia is generally used to make the procedure pain free.

Why the test is performed:

A biopsy may be performed to obtain healthy tissue so it can be evaluated for transplant tissue-type matching. Biospsies are more often done to obtain unhealthy tissue to diagnose disease.