I had a PFO closure this past February. I was exhibiting stroke symptoms and chronic migraine with aura, so my cardiologist (who also heads the PFO clinical trial at Duke) suggested I get it closed.
The procedure itself wasn't that bad - more weird than anything! My daily, unexplained headaches decreased about 50%. Although I still suffer from migraines triggered by everything from job stress to hormones, it's nice to not suffer daily anymore.
Despite what the clinical trials prove, I love knowing that my own migraines decreased and that the huge, gaping hole I once had won't be the cause of a stroke. I'm glad I had it done.