Resilience To Stress Plays Role in Depression
Migraine and depression are often comorbid diseases -- that means that people have them simultaneously, but neither causes the other. In the general population, 17% experience major depressive disorder. Among Migraineurs, that jumps to 47%. Given that, Migraineurs are often also interested in information about depression.
Researchers are making great progress in better understanding depression, including what causes it. This kind of research gives us more hope for better treatments...
- "An individual's emotional response to severe, acute stress (e.g., trauma, terrorist acts) or to more prolonged chronic stress (e.g., divorce, war-time torture) is determined by genetic and environmental elements that interact in complex and poorly understood ways... A majority of humans exposed to stressful events do not show signs of psychopathology such as posttraumatic stress disorder (PTSD) or depression... However, the neural substrates and molecular mechanisms that mediate resistance to the deleterious effects of stress remain unknown."
~ Krishnan et al
Results of a new study reported in the journal Cell may lead scientists along the path toward learning how to enhance a naturally occurring mechanism in the brain that promotes resilience to psychological stress. Studying a mouse model, researchers funded by the National Institutes of Health's National Institute of Mental Health (NIMH) found that the ability to adapt to stress is driven by a distinctly different molecular mechanism than the tendency to be overwhelmed by stress. The researchers mapped out the mechanisms — components of which also are present in the human brain — that govern both kinds of responses.
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