Teri, I keep coming back to this poll to see where the numbers are rising. Not surprising to see that they all seem, so far, to rise under not being able to do everday things.
Thank God for those in my life who are understanding. As for those who don't understand, oh well, I try to remain patient with their lack of knowledge.
I hate the pain but not as much as I hate the fact that while I feel great today I don't know what tomorrow will bring and making plans and then cancelling them is frustrating.
That is where determination comes into play. I am already a very determined person, stubborn, thick headed, etc. But, my unusual increase in my migraines over the last few years and having to quit my job has caused me to become more determined to educate those around me, myself and anyone who will give me their ear.
I am also very determined to keep pursuing the right treatment for me. I know it is out there just waiting for me to find it.
I mean, if I had to pick one. I guess it would be this one. I hate having cancel plans, or even worse, go through with them feeling horrible.
As a close second though I would say what it's done to my intimate relationship with my DH - not to get TOO personal but all the medications have to totally kill the 'ol drive?
Looking forward to hearing your responce too!!! 
For me it's definitely the depression and disability. Pain is fading into more of an irritant these days.
Having my own biology working against me and being taken on and off meds so often has been really hard. I've had a significant amount of depression in the last year that goes along with the migraines that I just can't shake. I can't use antidepressants and pushing Lamictal higher isn't an option, so I'm just stuck with tolerating it. My hope is that when the magical preventative is found, the depression will lift on its own as well. I have a really hard time dealing with chronic migraines and a mood disorder because they've been feeding into each other so much. I can't win.
The disability is really hard as well and helps fuel the depression. Constant pain keeps my concentration and memory off balance, which makes it very difficult for me to do my work and be a student. Some days are just impossible to function at all. I feel so behind in everything, and if it weren't for disability accomodations, I'd have to drop out. Nothing would crush my soul more than that.