Monday, May 28, 2012

Migraine Abortives and Rescue Meds Confusion

By Teri Robert, Health Guide Sunday, February 24, 2008
From recent conversations, it seems that there is some confusion about what medications can and cannot abort a Migraine attack. This can be important because, whenever possible, it is better to abort an attack than to simply treat the symptoms. There is growing evidence that Migraine is a progr...
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2/25/08 12:10pm

Thank you, Teri, for posting this clarification. I appreciate it when you provide clear and helpful information. It seems I've noticed a lot of confusion or miscommunication over which meds are preventive, abortive, or 'rescue' drugs, as well as confusion about which preventives are antidepressant, antiseizure,for blood pressure, and so on. It's enough to make us all crazy, but it's important for people to know what they're taking.

Betsy 

Anonymous
Stacy Devine
2/25/08 2:20pm

My problem is when to take the abortive meds. I have been in the hospital once for over use....do I wait until its a 4? That has been what I have been doing otherwise I would be taking meds ALL the time.

CONFUSED!

Anonymous
Anne Bülow-Olsen
2/26/08 3:44am

Dear Teri

 

Thank you for your comprehensive classification of the various migraine medicines into abortive, preventive and rescue medications.

 

From a biochemical point of view, the difference between the rescue medicines and the abortives is small, and the distinction may at best not be useful for migraineurs, and at worst give us the impression of effects that are not there.

 

Both types of medicine are absorbed in our bodies, do their job to counteract our experience of discomfort, and are decomposed and/or excreted after some time. When the concentration of the active compounds dwindles to a level where their effect disappears, we continue to experience the migraine as we would have done without the medication.

 

The action of the so-called abortive medicines (triptans and ergotamine) is, however, different from that of the various rescue meds, which are all painkillers. The triptans and ergotamine restore the diameter of the blood vessels (and may have a range of other effects as well), but if the chemicals that induced the vasodilation (NO, tyramine, phenylethyalmine, histamine or others) are still in the blood when the triptans/ergotamine have been excreted, the migraine returns.

 

Some doctors use the term 'rebound migraines' for the migraine that returns after the abortive treatment, but not for the returning migraine after rescue medication. This does not make a lot of sense,  biochemically. Migraine is countered by both types of medication as long as they are in the body in sufficient amounts. We just experience the remaining part of the attack when the medication has been excreted or decomposed.

 

The distinction between abortive and rescue medication may lead migraineurs and others to believe that the triptans and ergots actually take the attack away. They don't.

 

Research is showing that we get more irreversable brain lesions, the more migraines we experience, independently of whether we take triptans or painkillers. Therefore it is important that we do not classify the so-called aborted migraines as 'no migraines'.

 

We also know, from experience of many migraineurs, that  the number of attacks you get can be minimised by avoiding your personal triggers.  So for a migraineur who wants to preserve his or her brain, it is vital to identify his or her personal triggers and work on reducing the number of attacks.

 

It may not be easy to identify your personal triggers, but the prospects of having more changes in the brain than the general population get is certainly a strong motivating factor for me. There is quite a lot of information about triggers at The Danish Migraine Association's website http://www.migraeniker.dk/english/index_eng.htm

  

Hope this is helpful!

 

Anne Bülow-Olsen

Chairman, Danish Migraine Association

 

 

 

 

2/26/08 3:58am

Thanks Teri for the information. I have found it to be quite helpful.

 

As you stated, I have found that sleep is generally the best medicine. I also find that if I get a good night's sleep I am less prone to getting a migraine.

 

I have found sleep to be an awesome treatment. I will often take a medication, use a meditation tape to relax and then fall into a peaceful slumber as my body fixes itself.

 

Sleep can be a double edge sword, especially when one suffers from daily or almost daily migaines. I know that if I sleep too long I will wake up with a headache which may trigger a migraine.

 

I have had terrible insomnia through out my struggle with migraines and I find it very frustrating. After trying morphine last year, with minimal luck, the doctor prescribed Lunesta to help me sleep while I was coming off the morphine. I found it to be very helpful. It helps me get a good night sleep, with minimal side effects.

 

I am very aware of the dangers of taking sleeping aids and I weighed the pros and the cons and felt the benefits far outweighed the negatives. My doctor mentioned that he wasn't concered about addiction because I was able to go from 90 mg of MS Contin (morphine) a day in a relatively short period without a lot of problems.

 

My thoughts are if I can start the day off with a good night's sleep I'm already 10 steps ahead.

Anonymous
joyce
2/26/08 7:56pm

There are lots of things that trigger a migraine.

I found that listesning to relaxing music helps prevent them

.The music takes your mind off of stressful things. 

 Of course some of my miagraines start out as sinus headaches and then turn into migraines.  But using the music  still makes those less severe.

 colognes and perfumes I cannot wear cause they bring on a migraine.

Migraines also run in the family. 

  

2/26/08 9:01pm
i agree with your comments.that is why i recomend use Melatonin days before the prodromal period . refer to my articles on the pathogenesis of migraine.go on Google scolars. Dr joseph Toglia MD.
Anonymous
maria
2/27/08 10:55pm
this might be off the subject but, i have had migraines since i was a child that hit me so hard that i had to relieve my stomache and then i would pass out,i would sometimes become very confused at where i am .i am one of those people who medications do not work on me even in high doses. docters have tried.i find the method of a large bag of ice planted firmly on the facial area and crying sometimes helps i have other symtems i am starting to notice now and its starting to scare me, my family just doesnt understand how im feeling! what do i do
3/ 6/08 1:42pm

I didn't realize I was confused about my abortives and rescues until I read this post. Thank you so much for your helpful information. I wasn't even going to read your post, but I thought I would since I was bored and shocked myself. From now on I am going to read every post no matter how smart I think I am. Now I can make my next doctor's appointment more meaningful by asking them to go over the medications with me again!

 

Thanks a bunch!

 

Brianne

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By Teri Robert, Health Guide— Last Modified: 09/06/11, First Published: 02/24/08