A study published in the July 22, 2008, issue of Neurology®, indicates that taking the neuronal stabilizing agent (epilepsy drug) Topamax (topiramate) alone or along with other neuronal stabilizing agents during pregnancy may increase the risk of birth defects.
Research has shown that many medications of this type increase the risk of birth defects, but little research has been done on Topamax. Studies have shown that Topamax increases the risk of birth defects in animals. Maintaining effective epilepsy treatment during pregnancy is crucial because seizures may cause harm to the fetus.
For the study, researchers examined women who became pregnant while taking topiramate either on its own or along with other neuronal stabilizing agents. Of 178 babies born, 16 had major birth defects. Three of these were in infants whose mothers were taking only Topamax, and 13 were in those whose mothers were taking Topamax and other neuronal stabilizing agents...
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