Hi Nancy,
I know I sound like a broken record, but I am having some great success with Lyrica as a migraine preventative. I first learned about it when I read that the FDA had approved it for use for Fibromyalgia - another pain related disease.
My doctor says this is a second generation medication and has a lot less side effects. So far I have found this to be true. The one thing it does is intensify the effects of other medications. For example if I take two Tylenol 3s I get really tired (more than in the past) and have to sleep to wear off the effects.
Good luck. I can sympathize about how difficult it is to live with pain. I have been struggling as for a long time.
HappyArch
Dear Nancy:
It is great your MD is working with you to try different meds, and I hope the Zonegran improves your migraines. I know we are all different, but I had gone through about 30 meds or combinations of preventatives, including several antiseizure drugs and Lyrica. For me, an older antiseizure Depakote has helped the most with my migraines. I don't know about it's profile with regard to side effects on mood, but at least it's another to consider if you don't get results with Zonegran (maybe you have already tried it). You are still in my prayers and I hope you feel much better in the days ahead.
Clemmie
Dear Nancy - I so wanted that note to come off in the right way and hope you weren't offended by it. It sounded like I was so envious of your ability to have infusions at your neuro's office and I should have made it clear that I was happy that you can do that! 
This would have been a good week for me to experience that - I had a tough, intense 4 day migraine that was not responding to medication. Last night I was considering the ER. But I had to go back up on my daily pain regimen which I had been so proud of cutting back on. Sigh. So for now it is better. It is a subtle rise but amazing in the comfort level it returned. It is better than reaching for rescue meds all the time especially since my shedule is so busy. I hope sincerely that your migraine is improving or that you have found something to break the current cycle. I wish you a blessed Easter -
All the best with warmth and healing thoughts -
Ian
What kind of IV infusion treatments do you receive? Just wondering what they gave you.
Sherry
Hi Sherry,
The infusions I get in the doctors office consist of fluids, and magnesium sulfate. They also give me a shot of diluadid and vistrol.
For more information here is a link for you IV Treatment of Refractory Migraines.
I hope this helps. Let me know if you need more information.
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I hope this helps to make things more comfortable for you, and- dare I say it- the magic combo that makes the migraine monster have to release its grip on you and go cower in the corner.
Big Hugs,
J