I suffer from Basilar-Type Migraines. My neurologist placed me on Zonisamide 500mgs at bedtime 2 years ago. She did this after many other drugs failed to reduce the frequency or I became immune after period of time. I suffered many of the usual side effects; tiredness, loss of some short term memory (words during conversation, can remember how to spell , math, names don't come to me as easy)
Six months ago, I began to have tingling in one arm and numbness in both legs. The doctor lowered the Zonisamide dose to 400mgs.
Then two months ago, I would fine, be sitting and all of a sudden begin to sweat uncontrollably, when I would stand up I would experience a overwhelming loss of energy that would literly start at the top of my head and over take my entire body leaving me weak in a matter of seconds. I would immediately have to lie down. I can't remember anything once falling asleep. I will sleep for 2-10 hours in a coma like state totally exhausted. During this period people have tried to wake me. Later telling me that I would roll my eyes back into my head, try to answer in some unknown speech which they can not understand and fall back into a deep sleep. When one eposide hit my husband took my blood sugar (which always runs on the low side of normal) and it was 82. My doctor sent me for diabetic testing which came back fine. No diabetes.
So again the doctor lowered the Zonisamide this time to 300mgs. Now I am experiencing three very unusal things: 1. Voguing, 2. Brain warps, 3. Nightmares & Hallucinations.
1. Voguing - in the middle of the night I will awake to get a drink of water or go to the restroom and find myself blanking out in the middle of doing something. When I come around I am holding the position I was in at the time. For instance, last night, I was walking to the cabinet to get a glass for water and had my hand extended toward the cabinet. At the same time I was reaching with the other hand scratching my back. When I came to, my arm was extend out toward the cabinet and my other hand was on my back. It's almost as if I just freeze in time for a few seconds, but I have no knowledge of closing my eyes!
2. Brain Warps - At times I can be in conversation or in the middle of doing something and it feels as if my brain gets dizzy or warps. My concentration goes and I get tired almost immediately.
3. Nightmares & Hallucinations - In the last few weeks I have experienced nightmares I can not remember but willwake up swatting at things I see for a brief second.
I also take other medications for IBS, mild depression and high blood pressure but I have been on these same medications for years without any changes or side effects.
I am at a loss and my doctor is telling me she has never heard of any of these type side effects from Zonisamide.
My question is: Is anyone out there experincing anything like this or heard of this before?????
Thanks for listening....