I took Topamax for about 5 months with no side effects except numbness in my hands and feet. It really worked to reduce and almost eliminate my headaches. After 5 months I decided to go from 25mg to 50mg. I woke up one night with whole body shaking uncontrollably. I was also waking up for a while with my heart pounding. I thought for sure that this was due to the Topamax. This all ocurred during a stressful time in my life. I ended up giving up on Topamax and went back to having 20 headaches a month. Since then I have had two doctors tell me that my symptoms were not Topamax related. I do occassionally still wake up with a rapid heartrate. I am going to try Topamax again but this time take it in the middle of the day. I thought this might help me get over the anxiety of takeing it. Has anyone else had a similar experience? Do you have any advice for me? I have also considered asking about taking an anti anxiety med or sleep aid along with Topamax what do you think? Thank you for taking the time to read this.