Bad Topamax experience - worth trying Zonegran?

Ask the Clinician Health Pro
  • Full Question:


    I was taking Topamax for migraines, but thought I was losing my mind.  My head hurt, had eye pressure, no taste, memory loss, and visual problems.  My Dr. wanted to UP the dosage?


    After speaking with my GP, we titrated down on the Topamax.  I feel almost normal again, but the constant headache is there. Would a low dose of Zonegran be worth trying? I can't live like this, but certainly could not live with the Topamax side effects.


    Any suggestions would be great. Mary.





    Dear Mary;


    You're not alone in your experience with Topamax. Certainly, Zonegran is one option to explore with your doctor. It does have fewer potential side effects, and some patients who have not been able to tolerate Topamax have done quite well with Zonegran.

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    If you and your doctor decide to give Zonegran a try, be sure to taper up slowly. Zonegran has a 72-hour half-life, so we usually start patients on a low dosage every other day and build from there.


    Good luck,
    John Claude Krusz and Teri Robert



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    About Ask the Clinician:

    Dr. Krusz is a recognized expert in the fields of headache and Migraine treatment and pain treatment. Each week, he and Lead Expert Teri Robert, team up to answer your questions about headaches and Migraines. You can read more about Dr. Krusz or more about Teri Robert.


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    Last updated February 28, 2010.

Published On: February 28, 2010