7/9/07 #7 - Sister on Topamax for Migraines, causing her to be angry?

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  • Full Question:

    My sister has really bad migraines. She’s had them since she was 4-years-old; now she’s 18. Her doctor has her on Topamax for headaches, which causes her to be really angry. They also have her on Prozac for being angry all the time. Prozac has caused her to gain weight, but yet she still has very bad migraines. What should she do, and is their any other kind of meds she could take instead of these?



    Dear Worried Sister;

    Thank you for being so understanding and supportive of your sister. It’s very important that a Migraineur have such support.


    There are many, many, medications and combinations of medications that she could try instead of Topamax and Prozac. The list is too long to even begin to list them all here. Some of the types of medications that are often used for Migraine prevention include:

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    • Medications originally developed to control blood pressure and/or treat heart disease:

      • Beta blockers such as propranolol (Inderal)

      • Calcium channel blockers such as Verapamil (Verelan, Calan)

      • Angiotension II receptor antagonists such as candesartan (Atacand)

      • ACE Inhibitors such as Lisinopril

    • Medications originally developed to treat depression such as:

      • Tricyclic antidepressants such as amitriptyline, nortriptyline

      • Other antidepressants such as Effexor and Effexor XR

    • Medications originally developed to treat seizure disorders such as Depakote, Neurontin, Lamictal, Gabitril, Keppra, Trileptal, Zonegran and Topamax
    • Medications originally developed to treat arthritis such as Celebrex
    • Many more.


    Her best course of action may well be to seek care from a reputable Migraine specialist. Family doctors and general practice neurologists, no matter how well-intentioned, often just don’t have the experience and advanced training to adequately handle difficult Migraine cases. There’s a link below to our directory of patient recommended specialists


    Good luck,
    John Claude Krusz and Teri Robert

    If you need to find a headache and Migraine specialist, please see our listing of patient recommended specialists.

    About Ask the Clinician:

    Dr. Krusz is a recognized expert in the fields of headache and migraine treatment and pain treatment. Each week, he and Lead Expert Teri Robert, team up to answer your questions about headaches and Migraines. You can read more about Dr. Krusz or more about Teri Robert. If you have a question for this section of our site, please click HERE. Accepted questions will be answered by publishing the answers here. No questions will be answered privately.


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    We hope you find this general medical and health information useful, but this Q & A is meant to support not replace the professional medical advice you receive from your doctor. For all personal medical and health matters, including decisions about diagnoses, medications and other treatment options, you should always consult your doctor. See full Disclaimer.

Published On: July 07, 2007