Side effects from Amitriptyline - Doctor doesn't want to change it?

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  • Full Question:

    Hi, I am a 51 year old woman who has had migraines with aura since I was about 5 years old. In the past couple of years I have gained good control with the use of amitriptyline 10 mg. and atenolol 25 mg/ day. Lately I have been having bad side effects with the amitriptyline and want to go off it but every time I try I end up with a migraine for weeks on end. Is there something I could take in place of amitriptyline? My Dr. thinks that I should continue to take it because it works.


    Thank you,



    Dear Piper;


    There are many choices of medications for Migraine prevention. Amitriptyline is an older drug that is used less than it once was. You can find a list of possible preventives, including other antidepressants in Migraine preventive medications: too many options to give up!

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    If your doctor isn’t able to help you, it may well be time to consult a Migraine and headache specialist. It’s important to note that neurologists aren’t necessarily Migraine and headache specialists. Take a look at the article Migraine and Headache Specialists - What's So Special? If you need help finding a Migraine specialist, check our listing of Patient Recommended Migraine and Headache Specialists.


    Good luck,
    John Claude Krusz and Teri Robert



    To review other questions from our Ask the Clinician Column,
     browse the Ask the Clinician archives.


    If you need help finding a  Migraine and headache specialist,
     visit our listing of Patient Recommended Specialists.



    About Ask the Clinician:

    Dr. Krusz is a recognized expert in the fields of headache and  Migraine treatment and pain treatment. Each week, he and Lead Expert Teri Robert, team up to answer your questions about headaches and  Migraines. You can read more about Dr. Krusz or more about Teri Robert.


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    Last updated June 17, 2010.


Published On: June 17, 2010