Migraines began after Lupron treatment, haven't stopped?

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  • Full Question:

    I saw in one of your earlier "Ask a Clinician" posts (10/22/07) that you are familiar with cases in which onset of Migraine is induced by the drug Lupron.


    Have you heard of cases, such as mine, in which the migraine attacks decrease slightly in frequency and severity, but nevertheless persist for more than two years after the Lupron therapy (for endometriosis)?


    I have been on various and combined preventative medications and rescue medications to no great effect, while no one that I've seen has been interested in pursuing an approach based on the initial genesis of the disorder. Do you have any suggestions for treatments or tests that might be especially helpful or relevant in such cases?

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    Thank you for your consideration,



    Dear Lili;


    Migraine is a genetic neurological disease. The best information we have at this time indicates that the cause of the disease it genetics and overactive neurons in the brain. We have seen women who had not experienced Migraines before treatment with Lupron, but that doesn't change the cause of the disease. Those women probably simply had few triggers strong enough to induce a Migraine, and the Lupron caused them to be more sensitive to their triggers, was a trigger itself, or both.


    The Lupron would not still be triggering Migraines, son finding out what your current triggers are could help a great deal. One of the best tools for identifying triggers is a good Migraine diary. You can download a free diary workbook from our article Your Migraine and Headache Diary. Some of us have food triggers; some of us don't. It's advisable to determine if your daughter does, and an elimination diet is the best way to do that. For more information and a workbook on this, see Managing Migraine - Migraine Trigger Foods.


    The way patients respond to treatment varies so greatly from one to the next that it's virtually impossible to recommend any specific treatments for you. If your doctor isn’t able to help you, it may well be time to consult a Migraine and headache specialist. It’s important to note that neurologists aren’t necessarily Migraine and headache specialists. Take a look at the article Migraine and Headache Specialists - What's So Special? If you need help finding a Migraine specialist, check our listing of Patient Recommended Migraine and Headache Specialists.


    Good luck,
    John Claude Krusz and Teri Robert



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    About Ask the Clinician:

    Dr. Krusz is a recognized expert in the fields of headache and  Migraine treatment and pain treatment. Each week, he and Lead Expert Teri Robert, team up to answer your questions about headaches and  Migraines. You can read more about Dr. Krusz or more about Teri Robert.


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    Last updated June 12, 2010.


Published On: June 18, 2010