1/21/08 #2 - Zonegran for Migraines - bone loss?

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  • Full Question:
    Do you know of any reliable research on the effects of Zonegran usage on bone density in a woman of peri and post-menopausal age? Also, any reliable research into the effectiveness of Zonegran in preventing migraine? I have recently gone off Zonegran with my doctor's permission out of concern for bone density loss; however I have experienced an unacceptable return of migraine frequency, so I am considering restarting the medication again. I was allergic to Depakote and Topamax so those are not options. Thank you in advance for your response, Marilyn.




    Dear Marilyn;

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    Most of what I know about the effects of the Zonegran on bone density comes from studies done in rats! There is ONE case report in the Oriental literature on improvement of bone density loss after zonisamide with estrogen in an 18-year-old man. Apparently, the medication causes accelerated bone loss, but this is a speculation.


    Actually, I had the first data in the world literature on the use of Zonegran for Migraines (and for chronic pain disorders as well), so I feel I know a good data about this medication. Of course, the evidence speaks for itself in your case and I am personally glad you are taking the medication again.


    Good luck with the treatment of your Migraines,
    John Claude Krusz and Teri Robert


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    Last updated January 21, 2008.

Published On: January 21, 2008