1/28/08 #9 - Anticonvulsants for Migraine and bone loss?

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  • Full Question:
    I am a 49 year-old woman who has had migraines for the last fifteen years. I've been taking 500 mg. of Depakote and 50 mg of nortriptyline a day for several years. Recently, a bone scan showed that I have osteopenia. I read somewhere that anticonvulsants like Depakote can cause thinning of the bones. I am taking in lots of calcium and have been taking magnesium as a migraine preventative. I'm wondering now whether I should continue taking Depakote? (The Depakote seems to lessen the intensity of the migraines, although not the number of migraines.) Osteoporosis does run in my family. Thank you for your help, Paloma.

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    Dear Paloma;


    Most of the information on the bone density and anticonvulsants is taken from studies done with rats! I know of no specific effect of Depakote or your other medication to cause these problems. The family history speaks for itself and that probably will be a larger factor in the need for osteoporosis treatment.


    Good luck,
    John Claude Krusz and Teri Robert


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    Last updated January 28, 2008.

Published On: January 28, 2008