1/28/08 #3 - Compazine and medication overuse headache / rebound?

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  • Full Question:
    I recently saw a new migraine specialist for a second-opinion consult. This specialist diagnosed migraines (of course) and Chronic Daily Headache. She believes that my migraines have gotten so out of control because the initial migraine was under-treated, and then I fell into CDH by using too much Compazine (NOT OTC or prescription pain meds, triptans, Midrin, or other abortives). This was really news to me. Both my initial neurologist and my current migraine specialist know about my Compazine use and neither ever indicated that it could lead to rebounds. In fact, I was previously diagnosed with CDH, but it was noted that it was not due to medication overuse.

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    I've tried doing some digging on my own but have not found anything linking Compazine to CDH or MOH. My typical Compazine use is 3-4 (sometimes 5) days per week to help control nausea, and on days I'm lucky, it works as a migraine abortive. It's almost indispensable during my prodrome period, but I've agreed to cut down my use to 2-3 days per week. My question is, could Compazine be causing my problems? Thanks, Michelle.




    Dear Michelle;


    I know of no specific data that suggests frequent Compazine use is linked to rebound type headaches. If you’re current headache physician thinks this is possible, then I suggest he or she find you an alternative medication.


    Good luck,
    John Claude Krusz and Teri Robert


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    Dr. Krusz is a recognized expert in the fields of headache and Migraine treatment and pain treatment. Each week, he and Lead Expert Teri Robert, team up to answer your questions about headaches and Migraines. You can read more about Dr. Krusz or more about Teri Robert.


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  • Last updated January 28, 2008.

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Published On: January 28, 2008