I’ve read several different articles stating that anti-depressants can be used to prevent headaches and Migraines, but none of them talk about how they work to in prophylaxis. Can you explain? Thank you, Marijane.
Depends on what type of headache. There is very little positive data on tricyclic antidepressants (TCAs) and SSRIs having stunning effects on Migraines. There is no agent in either category that is officially approved for Migraine treatment in the US. Yet, many doctors use TCAs to suppress Migraines, and they do help in some cases. For treating chronic daily headaches, there is some data with these agents but, again, no agent is officially approved. The mechanism is not understood but it may have to do with their effects on serotonin in the brain.
John Claude Krusz and Teri Robert
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Published On: April 09, 2007