Top 75 Migraine and Headache Questions, #24

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  • Full Question:
    I have a question concerning the Triptan group of drugs used for migraine treatment. Does anyone know what causes one or more of these drugs to become ineffective over time? I used to take Imitrex and it stopped working for me after a few years. I now take Zomig, but it's not working as well as it used to; I'm afraid it's going to stop working for me as well. The question is-why do these medications work so beautifully at first, then after a while they just stop working?



    I don't know why either; nor does anyone else in the headache trade. 30-25% of my Migraine patients have to go to another triptan after the first one "quits". I have a rotation schedule to use different triptan for different patterns of Migraine. It is interesting that the two triptans you mention are the shortest half-life triptans on the market.

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    Good luck,
    John Claude Krusz and Teri Robert

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    Dr. Krusz is a recognized expert in the fields of headache and migraine treatment and pain treatment. Each week, he and Lead Expert Teri Robert, team up to answer your questions about headaches and Migraines. You can read more about Dr. Krusz or more about Teri Robert. If you have a question for this section of our site, please click HERE. Accepted questions will be answered by publishing the answers here. No questions will be answered privately.

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Published On: April 09, 2007