Top 75 Migraine and Headache Questions, #21

Ask the Clinician Health Pro
  • Full Question:
    I read in a newspaper article that the FDA has issued a Public Health Advisory to warn physicians of the hazards of mixing migraine medication such as Amerge, Frova, and Imitrex with anti-depression medications such as Paxil, Prozac and Zoloft because of the danger of potential life-threatening serotonin syndrome. What are you views on this? Julie.


    Dear Julie;

    Although the FDA advisory is new, the possibility of serotonin syndrome in these circumstances is nothing new. There have been warnings in the prescribing information for these medications all along. The incidence of serotonin syndrome is very low, but this is something you should discuss with your own physician so that your concerns are addressed in the context of your individual situation and the medications you take. You can read more in Triptans, Antidepressants, and Serotonin Syndrome.

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    Good luck,
    John Claude Krusz and Teri Robert

    About Ask the Clinician:

    Dr. Krusz is a recognized expert in the fields of headache and migraine treatment and pain treatment. Each week, he and Lead Expert Teri Robert, team up to answer your questions about headaches and Migraines. You can read more about Dr. Krusz or more about Teri Robert. If you have a question for this section of our site, please click HERE. Accepted questions will be answered by publishing the answers here. No questions will be answered privately.

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Published On: April 09, 2007