I read in a newspaper article that the FDA has issued a Public Health Advisory to warn physicians of the hazards of mixing migraine medication such as Amerge, Frova, and Imitrex with anti-depression medications such as Paxil, Prozac and Zoloft because of the danger of potential life-threatening serotonin syndrome. What are you views on this? Julie.
Although the FDA advisory is new, the possibility of serotonin syndrome in these circumstances is nothing new. There have been warnings in the prescribing information for these medications all along. The incidence of serotonin syndrome is very low, but this is something you should discuss with your own physician so that your concerns are addressed in the context of your individual situation and the medications you take. You can read more in Triptans, Antidepressants, and Serotonin Syndrome.
John Claude Krusz and Teri Robert
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Published On: April 09, 2007