Since I began taking BoTox for migraine many years ago, I experienced constipation with each round of injections.  But since I have IBS anyway, I didn't mind all that much.  However, now that the FDA recommended higher dosages when they cleared it for use in the USA, I had a very bad experience with this problem.  I had to take two stool softeners each night,  I had to take several fiber pills every morning, and I ate prunes by the handful.  My neurologist insisted that I was crazy, but when I told him of all the meds I had to take just to be able to go to the bathroom somewhat, he relented and put the needles elswhere.  I insisted he leave them out of my neck, as I had problems with my voice anyway, AND I went on line to find out where acupuncturists put in needles to help constipation, and it was in the neck.  Anyway, by moving the needles, I lost most of the pain relief.  I have got to find out exactly what placement causes the constipation.  I have two months left on this treatment, and my bowel habits have returned to normal.  Too bad my head hurts!  I have daily chronic migraines, by the way.