I have recently tried Botox injections for migraine prevention. The first round didn't help. The second round, a higher dose, may be helping a little - but I have found myself having problems with constipation (that increased significantly after the second round). I am not taking any pain meds other than very occasional ibuprofen and have not changed any other medications. I eat a hgih fiber diet. It seems odd to think there could be a connection - but I did a bit of reading on brain-gut relationship which made it seem not so far-fetched. Also, even before trying Botox, I had noticed that I tended to become constipated as my migraine was getting better. A strange thing. Any thoughts?