I am answering this years after it was first posted, but I am hopeful that my response might help someone else, too. Like another respondent, I had never had kidney stones, neither had anyone in my family. I am a vegetarian, do not drink colas, limit my caffeine intake, and do not injest enough dairy products to over do the calcium. I developed kidney stones and just passed a 5mm stone. I have another stone that is right behind it trying to pass, too. The CT scan shows my other kidney has a similar stone waiting to fall at some point in time as well.   I have loved how Topamax has kept me free from the debilitating migraines that I had developed. I was getting them every 3 to 4 weeks and it was agonizing. However, this is also just as debilitating and much more painful. I do not have insurance at this time and cannot afford Lithotripsy procedure to break up stones and pass them quicker. I'm going to have to off the Topamax -- at least for a while.   I admit I have also enjoyed the weight loss I've experienced with Topamax but I'll keep it off by eating properly and exercising!