Researchers have discovered why many fibromyalgia patients complain that even strong narcotic pain medications fail to relieve their pain. A study at the University of Michigan Health System found that the mu-opioid receptors (MOR) in people with fibromyalgia had a reduced ability to bind to the drugs targeting them. The researchers did positron emission tomography (PET) scans of 17 women who had fibromyalgia and 17 women who did not. Results showed that the fibromyalgia patients had reduced MOR availability within regions of the brain that normally process and dampen pain signals –– specifically, the nucleus accumbens, the anterior cingulate and the amygdala. Opioid medications work by binding to opioid receptors in the brain and spinal cord. When those receptors have a lowered availability, the painkillers may not be able to bind to the receptors as well as they should, which means they cannot alleviate pain as effectively. Among the drugs that would be affected b...
I took a oxycodone 5mg and 15 min later was given a toradol shot. Is this safe? Amy.
There are no significant interactions between these two medications to make the combination unsafe.
That said, it doesn't mean they're safe for you. It depends on more than those two medications. It also depends on all other medications you're taking and any medical issues you may have. Hopefully, you remembered to tell the doctor who ordered the Toradol about the oxycodone, and he or she considered that before ordering the Toradol.
Good luck, John Claude Krusz and Teri Robert
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It’s long been known that there is a link between chronic pain and depression , but a new study suggests there may be a connection between the drugs that treat these two conditions as well. In a recent issue of the Proceedings of the National Academy of Sciences, scientists found evidence that non-steroidal anti-inflammatory drugs (NSAIDs) significantly reduce the effectiveness of selective serotonin reuptake inhibitor antidepressants (SSRIs) such as Prozac, Lexapro, and Zoloft. In fact, NSAIDs – a class of painkiller that includes such commonly used drugs as aspirin, ibuprofen (Advil), and naproxyn (Aleve) – were associated with a 10 percent drop in depression remission rates, from 55 percent to 45 percent. What this means is that if you take NSAIDs and SSRI antidepressants together, there’s a 10 percent greater chance you’ll still suffer from depression, even if you’re taking a medication to treat it. Meds send conflicting signals in the brain...
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