Researchers have discovered why many fibromyalgia patients complain that even strong narcotic pain medications fail to relieve their pain. A study at the University of Michigan Health System found that the mu-opioid receptors (MOR) in people with fibromyalgia had a reduced ability to bind to the drugs targeting them. The researchers did positron emission tomography (PET) scans of 17 women who had fibromyalgia and 17 women who did not. Results showed that the fibromyalgia patients had reduced MOR availability within regions of the brain that normally process and dampen pain signals –– specifically, the nucleus accumbens, the anterior cingulate and the amygdala. Opioid medications work by binding to opioid receptors in the brain and spinal cord. When those receptors have a lowered availability, the painkillers may not be able to bind to the receptors as well as they should, which means they cannot alleviate pain as effectively. Among the drugs that would be affected b...
There was an article in the New York Times recently about a couple away on a lovely vacation in Indonesia and the husband accidentally fractures his ankle. Not so lovely. Their cell phones turn out to be the most reliable tool they have. They make the decision not to have surgery in a foreign country and then have to figure out how to get him home.
It all sounded rather painful and unpleasant. His ankle fracture and subsequent pain reminded me that I still have 49 Percocet tablets in my cupboard.
Let me explain.
I had surgery in the early fall. As part of the post-op pain management plan they prescribed Percocet, 50 pills. The prescription reads: one or two, every three to four hours as needed, enough for days upon days upon days. Too many pills in my opinion, way too many.
I had taken one right after surgery in the recovery room for pain I didn't yet feel and one more when I got home. That evening, I had horrible withdrawal from all of the medication and certainl...
If you depend on ketorolac (brand name Toradol) injections for Migraine treatment, it would be wise to contact your doctor to find out you should use in it's place for the foreseeable future.
Doctors, pharmacies, and emergency rooms are reporting shortages and outages of injectable ketorolac. The FDA web site lists ketorolac injection in their drug shortages section. Various manufacturers list shortages, giving different reasons including manufacturing delays, increase in demand, and raw material shortage. None list any anticipated dates by which they expect the shortage to be resolved.
Ketorolac is an NSAID sometimes used in injection as a rescue medication when Migraine abortives fail or can't be used. The brand name of ketorolac was Toradol, which was discontinued some time ago. For more information, see Preventive, Abortive, and Rescue Medications - What's the Difference?
If ketorolac is your rescue medication, please contact your doctor now about an alterna...
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