aztec57,  I work in a pharmacy and can tell you that by law, the active ingredient in a generic is the same as in the name brand.  The difference is in the compounding agents or inactive ingredients.  That doesn't mean that you can't be effected by these inactive ingredients.  I'm taking sumitriptan myself (generic imitrex) and I did notice differences, though not in it's effectiveness.  It most certainly isn't "you".  People all have very unique reactions to medications and the generic might not work for you.  If this is the case and you have Rx insurance, be sure to have your Dr. write your script for the brand name and sign it no substitution allowed.  You'd be surprised how many insurance companies refuse to pay for the name brand when there is a generic available, even when the patient is requesting brand.