Good question! I spent some time earlier this week corresponding with the FDA to see if any of the so-called generics were going to be available. The short answr is, "probably not." You can read their full response in Midrin for Migraine: What's Going On?
To the question of what can be used as replacements...
Midrin has been a dual purpose medication. It worked as a Migraine abortive for some people, and for others, it worked well for tension-type headache. Unfortunately, Midrin and the other isometheptene mucate / dichloralphenazone / acetaminophen compounds were unique. There is no equivalent replacement.
For Migraine abortives, there are several options:
There two main types of abortive medications left, triptans and ergotamines. The triptans are newer and prescribed more often. There are seven medications in the triptan family-- Imitrex, Maxalt, Zomig, Amerge, Relpax, Axert, and Frova -- as well as Treximet, which is a combination of Imitrex and Naproxen Sodium. Each of the triptans binds to different combinations of serotonin receptors, which is why our bodies may respond differently to each of them. It's well worth discussing the ones you haven't tried with your doctor.
If none of the triptans work well for you, you can also ask him about Migranal Nasal Spray or DHE injections that you can give yourself at home. There are a few other ergotamine medications, but Migranal and DHE are the most commonly prescribed.
The problem comes in if you have a history of or risk factors for stroke or other cardiovascular issues because the triptans and ergotamines are generally not recommended for patients with those issues. In some cases, doctors may make exceptions and prescribe them if they feel the risks of the Migraines are worse than the risks of the medications. Otherwise, doctors may prescribe NSAIDs, opioids, or other medications usually reserved for us as rescue medications when abortives fail.
The best thing to do is have a good discussion with your doctor about which of the remaining options are best for you.
I hope this gives you the information you need.
I was also upset to hear that the wonderful Midrin was discontinued. I saw one of the postings that said to go to a compounding pharmacy and they were able to make it for me. I picked it up today. Before I left, though, the pharmacist said he was not able to get one of the ingredients anymore, but had found it at another pharmacy for my order today. So, I recommend going immediately to a compounding pharmacy and getting them to make it immediately. Several pharmacies that I called did have all of the ingredients currently on hand. I got 100 pills and hope that buys some time until another medication that works for me can be found.
I have been taking Imitrex for year's and always had side effects with this type of medication. My doctor just this month prescribed what the pharmacist called midrin. I find that I am taking it more often than I noticed taking other medications (at least 3 times a week). I guess I should go ahead and get a refill of the medication since everyone says that it is not available anymore.
I went to a compounding pharmacy in Dallas, TX called Dougherty's. It has been around since the 1950's and the people are really nice. They also do mail orders but the pharmacists who gave me the script said it was the last batch (I think it was about 4 or 5 perscriptions worth and mine had 60 pills) of it that he had. He is trying to find the compounds. I had never heard of this before and he said it will likely be my miracle drug. You could give them a call and see if they still have some. They have a website doughertys.com. Hope this helps
I was having the same trouble as all of you guys were - desperate for my midrin. Heck, I was using "vintage 2008" midrin with extra prescription ketoprofen chasers there for a long while. I finally found a compounding pharmacy here in Delaware that could get all of the ingredients in midrin and make me some. It took a long time to get the one ingredient that everyone else has had trouble getting but they got it in stock a couple of weeks ago. I had them remove the acetominaphen (sp) from the formula and replace it with prescription ketoprofen for me because I've used it successfully for years and since its in NOTHING you can't possibly overdose on it unless you take too much (ie its not hiding in your cold meds etc). They even special ordered red capsules for me so it would look closer to name-brand midrin, which also is useful since for 20+ years my migraine meds have been red and all of my other painkillers etc have been white or blue - makes grabbing a dose when you're in pain and not able to concentrate much easier. Since somebody else posted the name of their pharmacy I hope its not a problem if I post mine - the pharmacist promised me he ordered enough ingredients to make some for other people and that he'd ship. He felt really bad for me once I explained how much of a problem the lack of midrin was for so many migraine sufferers. After all, it was my only prescription for migraines for over 20 years... But anyway, its Saveway Compounding Pharmacy located in Newark Delaware. Quick internet search will find it. If you email them and say you heard they can make midrin they will know exactly what you want. You'll just need your doctor to write the script with the ingredients (feel free to sub out another pain killer, they can do that). Then you can ask for different colored capsules or whatever you want. When I ordered 60 pills (with refills of course) with ketoprofen it ran around $1 a pill - which I was thrilled to pay. Pharmacist told me some insurance companies will reemburse too.
I would like to share this information with all my friends that have same question and confusion in mind about Midrin or Midrin Equivalent. There is a new Compounding Pharmacy in town called, 15RX Pharmacy at State Hwy 151 and Military drive. There ph. no. is 210-684-1579. You can google there address or call them to find out more info. They are nicest people who work closely with doctors to find solution to problems like this. My friend just got her Midrin equivalent filled with them and is really satisfied.
Hope this helps!
Did they say "why" they discontinued it? Was there something in it that was dangerous?
I am in the boat with the rest of you. Woke up with a killer migraine (again) and have only a few generic Midrins left....
The new medicine she gave me doesn't work at all.
Anyone know why they took it off the market?
I used midrin for some time and when i could not find it any more my doctor suggested Prodrin. for all of you that found midrin really effective, i can tell you prodrin at least for me is even better. i find the symptoms go away very quickly and last. only downside is cost. i am on aetna and its still about $1 a pill. as a family member said its the best dollar you can spend. so except for cost--this is a perfect replacement for midrin. hope this helps robert
Funny, I was going to post my post-Midrin experiences too. What I've found is that if I have an onset during waking hours (aura, blind spots) so that I can dose myself, the Prodrin works quite nicely. As I understand it, Prodrin doesn't have the sedative of Midrin so it's easier to continue to function while medicated. The story isn't as rosy for my nighttime onsets...
I awoke yesterday with what felt like a mild headache. I figured that after my morning cup of coffee (1 cup, daily, I've found buffers my system for better resilience to caffeine...but if I miss that one cup, hello migraine), the headache would probably go away. Bad assumption. By 10AM I was in a meeting and the pain was so intense that I was nauseous. I left the meeting, took a Prodrin, and went home to sleep it off. I woke up with the migraine diminished, had lunch, and returned to work. But the migraine returned in full force and by the time I went to bed last night, I had two more Prodrin in my system and resisting the urge to be sick. I awoke this morning and things were back to normal, thankfully.
Midrin was more effective for me with the nighttime onsets. This was the 3rd or 4th time that I've been through the scenario above with Prodrin. My script says I can take 1 or 2 pills and I've only been taking 1 because it's new to me, so the next time I'm going to hit it with 2 and cross my fingers. I've posted here how the triptans have - or rather haven't - worked for me. I've all but given up on Fioricet, it's a lost cause with my migraines.
Brave new world without Midrin, and I'm too stubborn to try the compounding Pharms. If the drug co's can't get all the ingredients, it seems like it's only a matter of time before the compounders can't. Might as well adapt now.
After a three-day migraine and a dwindling supply of Midrin, I decided to renew my efforts to find the drug. I've already cleaned out all of my local pharmacies. Here's what I found out. My local compounding pharmacy and my local pharmacy all have the generic brand NOW in stock! Aug. 19, 2011. I told my doctor this and he immediately called in my prescription. I got a bottle of 100 -- the label has this information on it:
Isometheptene Mucate, Dichloralphenazone and Acetaminophen Capsules, USP 65 mg/100 mg/325 mg. The manufacturer is Macoven Pharmaceuticals, LLC of Magnolia, TX. I have never heard of this manufacturer.
Hope this helps others! Good Luck!
My migraines are to the severity level that they cause temporal lobes seizures, I blackout ending up in the hospital. In May 2011, the hospital doctor gave me MIDRIN. The migraines stopped. When she prescribed the medication for me, my pharmacy said this product was no longer available. I'm having terrible "blackout" migraines, confusion again. I'm on Prodrin but it doesn't help without sedatives. Two new neurologists are not helpful. What medication do you suggest to stop the migraines?
Hi everyone. I wanted to let you all know that I actually was in contact with Macoven Phamaceuticals this morning 4/27/2012. They do make and distribute the generic form of Midrin but do not call it Midrin they call it: Isometh/Dichlor/APAP. Here is the email with the information. Turns out it is available at Walmart, Target, Walgreens and CVS. I just got off the phone with my local walmart here in Washington and they stock it. It comes in a 60 capsule supply and runs about $95. I just had my doc call in to get a new script! Hope the rest of you can locate this in your area. If not, contact the Macoven directly at:
Yes, our product is called Isometh/Dichlor/APAP. It is available at any Wal-Mart, Walgreens, Target or CVS.
Thanks and have a great day!
RE: Trying to locate Isometheptene Mucate, Dichloralphenazone and Acetaminophen Capsules, USP 65 mg/100 mg/325 mg
After battling migraines for ten years, Midrin was the only thing that worked for me. When they got extremely severe occassionally I would have to go to the ER fot either Nubain/Phenergan ot Vistaril or Demerol/Phenegan injection. After I could no longer get generic Midrin thanks to the FDA... I had to take Stadol nasal spray and then because it was too strong, Lortab, poor choices since opiates can cause rebound headaches. I finally started getting Midrin compounded locally. The price went from $5 copay to $130 as my insurance didnt cover compounded meds. luckily I am an RN and explained my situation to a doctor who both trusts me and was willing to work with me for an alternative. I know most doctors would never Rx chloral hydrate these days as it has been displaced by safer meds and has a narrow therapeutic range... He agreed, after I approached him with the idea. I take 2 BC powders or 2 Excedrin migraines and a Somnote which he does Rx for me. BC contains caffeine, an effective cranial vasoconstrictor as well as Tylenol and the aspirin also helps. It works wonders. Though each somnote does contain 500mg chloral hydrate. Fortunately I am minimally affected by sedatives and it doesn't make me sleepy.
I doubt this is an option for the majority. True: most doctors pro ably won't even use CH anymore, much less at the responsibility of the patient taking the correct combination of OTCs with it. All I can say is shame on the FDA. The drug is so old that it has stood the test of time as safe yet it is old and has not undergone the newer clinical trials, but millions have found relief in Midron when either nothing else worked or they, like myself, couldn't afford triptans at $75 For six maxalt!... This leaves three optiow doctors are forced to prescribe less desirable AND less effective combinations containing narcotics
Good news - a generic of midrin is back on the market. It is made by Macoven. I went to the pharmacy today to have my Midrin compounded and was told there is a generic. She actually filled my prescription with the generic. Interesting it cost over $20 more than compounding but happy it is back. Now my insurance will pay for it.
Warning - it is back on a temporary basis. Hopefully, it will become permanent.
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