This makes me angry for her and you. I took topamax for a year also - at the insistence of my doctor. You know sometimes I think that doctors don't have your best interest at heart. Sometimes I think they just want to be courted by drug companies. Your wife needs to tell your doctor that she isn't taking it anymore period, or find a new doctor. After a few months of being on it, I told my doctor how much I hated it. He lowered my dosage, put me on anti-depressant to cope with the side effects and sent me on my way.   Finally I couldn't take it anymore. The last straw was when I had the worst panic attack. It wasn't worth it anymore, and it never helped with my headaches either.   But I know what you are talking about. Topamax caused a lot of problems between me and my boyfriend. I was very angry, depressed, anxious and neurotic. He even talked ot his mom about it - aparently he told her that he didn't know if we could stay together if I was going to be like that.   I'm so sorry to hear about your problems. It is hard to enough to deal with migraines. Headaches already cause strain on relationships. If topamax isn't working and it hasn't worked for a year - it's time to try something new. I know exactly how your wife is feeling. I felt like I completely lost myself, and that I was constantly going crazy. It's a horrible feeling. I got off topamax in March. I felt like a fog lifted. I'm finally myself again and it's wonderful. Good luck to both of you