Judy,   The combination of Phenobarbital and Depakote is pretty complex. Here are a few issues I found with this combination:   • It is important to monitor the levels of both medications.• Caution is advised as this combination may decrease Depakote levels and efficacy.• This combination can also increase barbiturate (Phenobartibal) levels.• There is a risk of toxicity.• The combination may increase the risk of central nervous system depression and psychomotor impairment.   Please keep in mind that this information cannot replace information and advice from your doctor. You really should discuss this with your own doctor. OK?   Teri