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Hi Robert,
I have not had these but have suffered from terrible bouts w/migraines. After trying everything (and not hearing good things about Topomax), I stopped eating chocolate and sugar. Low and behold I went from 9 days a month of migraines to only 1 or 2 - WOW! (I also don't do caffeine or alcohol, haven't for a long time). I don't know if cutting out sugar would help your wife, but anything is worth a try when you are suffering. Any time someone hands me a piece of cake or something sugary, all I have to do is think of the terrible pain, and the sweets are not worth it. Good luck to you and your wife, I hope she improves!
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