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Friday, December 05, 2008 onecent, Community Member, asks

Q: Has anyone undergone the Raskin Protocol (a 3 day treatment of DHE45 in the hospital for migraine)

My new neurologist (the fifth one in 3 years) says I have transformed migraine, that my daily headaches are really migraines, just not bad ones. He wants me to have the DHE 45 treatment this month and says it should break the cycle of constant migraine state and afterward I should only have episodic migraine (2-3 a year). That sure would be nice. Has anyone had any experience with this? I usually have 2-3 bad migraines a month.

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Answers (6)
kja, Community Member
12/ 6/08 10:06pm

I don't exactly know what the protocol is but I did have a DHE infusion once for a horrendous migraine. I too was experiencing relentless migraines. I was given one dose of DHE as a "short stay patient" The downside was I had to wait 24 hours after my last dose of immitrex that hadn't worked. I was in the worst pain ever prior to that. They usually give you something for nausea before because it can make you sick briefly.

The best part was it worked! I still have migraines more often than I want but it did work.


HemiGirl, Community Member
6/10/09 10:02am

I have had this treatment.  They generally give you the DHE-45 every 8 hours via IV along with other support meds (for nausea, etc.). I had a very similar intractable/transformed migraine for over 6 months and after this treatment, was migraine free for over 2 years.  My current neurologist has prescribed me the DHE-45 for subcutaneous injections at home when needed (one to two doses) for a migraine and this seems to work for me.  I am glad that it is, as none of the 'triptan' based drugs provided any relief for me.

ladyjake21, Community Member
7/28/09 3:34pm

I was wondering where you had this treatment done?  I should have my own room and nurse at the hospital where I live since I have had so many migraines that the imetrex wouldn't touch.  I was wondering how long you have had migraines?  I have been to 5 different neurologists and have had no luck. Thanks

ladyjake21, Community Member
8/23/09 7:37pm

I just recently underwent this protocol-after 5 different neurologists.  So far it has worked great.  The only thing I cant control is the pressure changes that trigger some of my migraines.  What I can understand is why this protocol wasn't tried earlier.  It won't cure them just break the cycle and I can give myself shots of the DHE at home when one triggers.  Good luck and I hope that it has worked if you have received the treatment

topper115, Community Member
6/26/10 2:28am

I had this treatment about 6 years ago and have had about five migraines since then. The treatment works. I took Botox injections following the treatment for 3 years which really helped prevent the migraines but now I never seem to have them. I had migraines for two years almost solid without relief before the DHE-45 treatments. I went into the hospital as an in-patient for the treatments and then started the Botox injections every 3 months following.  It was the best thing that ever happened to me.  I tell everyone this is the best thing to do if they have on-going migraines that can't be cured with the regular migraine medicine.  Do it. You won't regret it.

Nancy, Community Member
7/17/10 9:58am

My 15-year-old son underwent this treatment after a 2-month-long migraine. It was a big ordeal with being in the hospital and all, but it was the only thing that worked for him. It was a miraculous relief! Now his is on daily preventative meds and (cross our fingers!) this should never happen again. I don't know why more neurolgists don't use this protocol. It is a little drastic, but sometimes drastic measures need to be taken. NOTHING else worked, and this TOTALLY got rid of it!

Lori, Community Member
11/ 5/10 7:54pm

i have had migraines for 14 yrs and started to have them every day for the last 3 1/2 weeks so my neurologist sent me for a infusion of DHE45 it hasn't even touched my headache ( i take zomig and relpax for my migraines and they had stopped working) i go back in the morning for another infusion

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By onecent, Community Member— Last Modified: 02/27/14, First Published: 12/05/08