I started taking 25 mg topamax a few months ago and was supposed to go up to 50 mg but never did. The side effects started immediately. I had tingling hands and feet, and felt kind of weird like I shouldn't be driving or anything. I couldn't drink cola the next day. I was not hungry for about a week. After about two weeks most of the weird stuff started to get better after a month hardly no tingling. I never went to 50 because my hair started to fall out really bad. I went back to the doctor and he told me to take vitamin biotin 2000 mcg and it has slowed a little. I still have headaches, but no severe ones. I will run out in two weeks and I will stop taking it. Remember everyone is different the only thing I liked about it was I lost 5 pounds and I'm full of energy. Good Luck.