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I just went to a neurologist (finally) 7-31 due to major increase in migraines and reduced effectiveness of Relpax.  He put me on the Treximet and I have had faster relief.  It still has the wierd buzzy feeling that I got from Imitrex for about 45 minutes after taking it,  but is working better than the Relpax did.  Also  have FINALLY listened when he told me to take it at the firs tonset of a migraine rather than wait to see if it really is one. t is not a daily preventative.  I was also put on a calcium beta blocker with no side effects to note and am not sure if I havve reduced frequency but am willing to give it a few months.