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Hi Kim,   I'm sorry to hear your daughter is suffering so. You can find plenty of information on various treatments for Migraine disease to discuss with your daughters doctor right right here on our site. Let me see if I can help you there.   First, I know it may feel as if your daughter has tried every Migraine medication available, but there are so many more options that can be used for Migraine and headache prevention that it's literally impossible. There are over 100 medications to try! Don't lose hope yet. Take a look at this article: Migraine Preventive Medications - Too Many Options To Give Up!   When Migraines don't respond to treatment, they're termed intractable. In such cases, there are several medications that can be administered through IV infusion to get the cycle broken. You can find more information in IV Treatment of Refractory Migraine. DHE is one such medication on this list.     Good luck Nancy   PS check your messages!!