Hi Chris,
Depakote ER is one of four drugs approved by the FDA for Migraine prevention and used by many Migraineurs. The other three medications are Topamax, Inderal and Blocadren.
Potential side effects will vary from person to person, and in fact, may lessen as our bodies adjust to the theraputic dose. Lots of Migraineurs have good luck with this medication. In some cases it can take up to three months to see a reduction in our Migraine frequency and severity when we start new medications. If we don't give new medications enough time to work, we aren't being fair to the drug or ourselves.
I hope this helps,
Nancy