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Probably not, but false positives do occur.
Drug screenings are meant to do one of two things:
1. Identify illicit drug use, not the use of medications that are prescribed for you.
2. Verify that patients are taking their medications as they should be.
Just take your prescription bottle with you when you go for the screening, and you won't have any problems. Remember to tell them about all medications you're taking, including over-the-counter meds and supplements.
You can read more about this in Migraine Medications and "Passing" Drug Screenings.
It all depends on the detailed nature of the drug test itself. A standard drug test that is usually utilized for employment and housing consists of a five panel testing method that assesses for Amphetamines, Cannabinoids, Cocaine, Opiates, and Cyclics. There are other in-depth testing methods that can classify the details of other drugs. Overall, it depends on the specific nature of the test it-self. Each of the testing methods should have a area or process to list / report any specific medication that you are currently taking. With a valid perscription a medication that tests positive on a correlating test can not be held against an individual in a negative light.